STeMiN® is thecosmetics raw materialfrom human adipose-derived stem cell culture medium developed through many years of stem cell research experience.
Toxicity and safety test have been completed in accordance with FDA guidelines.
Selected as ‘Next Generation World-Class Product’ by the Ministry of Trade, Industry and Energy (2022)
STeMin® is rich in exosome content, a substance secreted from theadipose stem cells that is involved in the skin regeneration and antioxidants.
Effects
01
Antioxidant action
02
Skin regeneration
03
Suppression of immune response
04
Whitening
05
Moisturizing
06
Wrinkle improvement
Effects
Suppression of immune response
· Skin irritation induces the secretion of inflammatory cytokines such as interleukin-1α (IL-1α) along with structural changes in keratinocytes, which can worsen into the dermatitis in severe cases.
· This is effective against the atopy and skin rashes due to its immune response suppression effect.
· Skin clinical test results
[Improved skin soothing effect after 2 weeks of use]
· Test institute : OATC skin clinical center· Candidate : women over 40 years of age· Period : 23.03.10 ~ 23.03.24
*Limited to raw material characteristics
Tissue regeneration and wrinkle improvement
For skin regeneration, the increase in collagen secretion and binding amountof hyaluronic acid is required, and STeMiN has confirmed such effects.
• EGF (Epidermal Growth Factor) is an “epidermal growth factor” that is the cell growth promoter present in our skin and plays a role in healing the skin wounds, maintaining the elasticity, and stabilizing the damaged skin.
• VEGF (Vascular Endothermic Growth Factor) is a growth factor that induces the blood vessel formation.The development of vascular tissue, including skin regeneration and hair growth, and the supply of oxygen and nutrients through this development are essential.Therefore, VEGF is used as the very important factor in wrinkle prevention, anti-aging, and skin regeneration.
· Skin clinical test results
[Tissue regeneration and wrinkle improvement]
*Nasolabial fold area decreased by 24.60% / wrinkle depth decreased by 14.17%
· Test institute : OATC skin clinical center· Candidate : women over 40 years of age· Period :23.06.19 ~ 23.07.17 (4 week)
Before
After
Before
After
Before
After
*Limited to raw material characteristics
Whitening
This product contains a whitening composition containing the proteins derived from mesenchymal stromal cells and is effective in improving the skin brightness and transparency.
· Skin clinical test results
[Improved skin brightness and transparency after 2 weeks of use]
· Test institute : OATC skin clinical center· Candidate : women over 40 years of age· Period :23.03.10 ~ 23.03.24
*Limited to raw material characteristics
Growth factors
· Vascular endothelial growth factor (VEGF)
· Basic fibroblast growth factor (bFGF)
· Platelet-derived growth factor (PDGF)
· Hepatocyte growth factor (HGF)
· Fibroblast growth factor (FGF)
· Epidermal growth factor (EGF)
Extracellular matrix
· Type I collagen
· Hyaluronic acid
Reference
· Journal of dermatological science (2007) 48, 15-24
· Journal of dermatological science (2008) 49: 133-142
· Wound rep reg (2007) 15: 540-548
· Brain pathol (2007) 17: 263-275
· Circulation (2004) 109 : 52-58
Related patent
Immune response suppression
· Composition for suppressing immune response containing proteins derived From mesenchymal stem cell
· 10-1646236 / 2016.08.01 / KR
· 6273036 / 2018.01.12 / JP
Tissue regeneration
· Composition for tissue regeneration containing proteins derived from mesenchymal stem cell
· 10-1716850 / 2017.03.09 / KR
Whitening effect
· Composition for whitening containing proteins derived from mesenchymal stromal cells
· 10-1716850 / 2017.03.09 / KR
Promoting the extracellular matrix production (Enhancing the collagen synthesis and skin elasticity: Wrinkle improvement)
· Composition for promoting the synthesis of extracellular matrix containing proteins derived from mesenchymal stem cell
· 10-2113492 / 2020.05.15 / KR
Related thesis
Whitening and moisturizing enhancing effects of three-dimensional human adipose-derived mesenchymal stem cell-conditioned medium-containing cream
2023, Journal of Cosmetic Dermatology
Jaehi Kim, Sunray Lee, Yeon Kyung Lee, Bomi Seong, Hyung-Mo Kim, San Kyeong, Wooyeon Kim, Kyeongmin Ham, Xuan-Hung Pham, Eunil Hahm, Ji Yeon Mun,
Mukhtar Anthony Safaa, Yoon-Sik Lee, Bong-Hyun Jun, and Hyun-Sook Park
Effects of Cream Containing Three-Demensional Human Adipose-Derived Mesenchymal Stem Cell Conditioned Medium Secreting Growth Factors on Skin Elasticity
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The Effect of Three-Dimensional Cultured Adipose Tissue-Derived Mesenchymal Stem Cell-Conditioned Medium and the Antiaging Effect of Cosmetic Products
Containing the Medium
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Kyung Hye Kim, Yun-Sik Kim, Sunray Lee and Sungkwan An
Inhibitory Effects of Three Dimensional Adipose Tissue-Derived Mesenchymal Stem Cell Conditioned Medium on Immune Response and Efficacy Evaluation of its Cream
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